RJ Reiter Melatonin : That Ubiquitously Acting Pineal Hormone
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Melatonin, its agonists in pain modulation: clinical application
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone secreted by the pineal gland of all animals as well as in human beings. It is not only synthesized in the pineal gland but also many other organs like eye (Cardinali and rosner, 1971), gastro-intestinal tract (Bubenik, 2002), skin (Slominiski, 2005), lymphocytes (Carrillo-Vico et al., 2004), thymus (Naranjo et al., 2007) etc. Besides being a...
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The neuroendocrine and immune systems help an organism cope with changing environmental conditions. In recent years, melatonin, a neural hormone synthesized and secreted primarily by the pineal gland (Pelham et al., 1972; Pang and Ralph, 1975), has been suggested to have immunomodulatory roles. The involvement of melatonin in the establishment of a pineal-immune system regulatory axis is curren...
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Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously distributed and functionally diverse molecule. The mechanisms that control its synthesis within the pineal gland have been well characterized and the retinal and biological clock processes that modulate the circadian production of melatonin in the pineal gland are rapidly being unravelled. A feature that characteriz...
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Failure of isoproterenol (ISO) injections to raise pineal melatonin content has generated doubt about beta-adrenergic control of the melatonin rhythm in Syrian hamsters. However, the effect of ISO injected at night after light-induced reduction of pineal melatonin has not been reported. In this study, light exposure began at 6 1/4 h into one (normally 10-h) dark phase. The hamsters were injecte...
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تاریخ انتشار 2002